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Rusfertide

Chemical Structure : Rusfertide

CAS No.: 1628323-80-7

Rusfertide (PTG-300, PTG300)

Catalog No.: PC-28065Not For Human Use, Lab Use Only.

Rusfertide (PTG-300) is a peptidic mimetic of hepcidin that binds to ferroportin and decreases iron delivery to bone marrow, reducing the production of red blood cells, shows potential for polycythemia vera and hemochromatosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rusfertide (PTG-300) is a peptidic mimetic of hepcidin that binds to ferroportin and decreases iron delivery to bone marrow, reducing the production of red blood cells, shows potential for polycythemia vera and hemochromatosis.

Physicochemical Properties

M.Wt 2441.95
Formula C114H181N27O28S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Lysinamide, N-(3-methyl-1-oxobutyl)-L-α-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-cysteinyl-L-isoleucyl-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-prolyl-L-arginyl-L-seryl-L-lysylglycyl-L-cysteinyl-, cyclic (6→16)-disulfide

References

1. Kremyanskaya M, et al. N Engl J Med. 2024 Feb 22;390(8):723-735.

2. Modi NB, et al. Eur J Haematol. 2024 Sep;113(3):340-350.

3. Chew LP, et al. Leuk Res. 2025 Dec;159:108132.

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