Ruxolitinib S enantiomer |CAS:941685-37-6 Probechem Biochemicals

Chemical Structure : Ruxolitinib S enantiomer

CAS No.: 941685-37-6

Catalog No.: PC-45873Not For Human Use, Lab Use Only.

The chirality of Ruxolitinib (INCB-018424), which is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively..

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Biological Activity

The chirality of Ruxolitinib (INCB-018424), which is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.

M.Wt	306.365
Formula	C17H18N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)-

1. Quintás-Cardama A, et al. Blood. 2010 Apr 15;115(15):3109-17.

2. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.

3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16;363(12):1117-27.