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Chemical Structure : Ruxolitinib phosphate
CAS No.: 1092939-17-7
Catalog No.: PC-45874Not For Human Use, Lab Use Only.
A potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $48 | In stock | |
| 50 mg | $88 | In stock | |
| 100 mg | $120 | In stock | |
| 200 mg | Get quote |
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A potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively; displays modest selectivity against Tyk2 (6-fold) and marked selectivity (>130-fold) against JAK3; inhibits IL-6 signaling (IC50=281 nM), and proliferation of JAK2V617F(+) Ba/F3 cells (IC50=127 nM); suppresses erythroid progenitor colony formation from JAK2V617F(+) polycythemia vera patients (IC50=67 nM) in primary cultures; markedly reduces level of inflammatory cytokines, and preferentially eliminates neoplastic cells in a mouse model of JAK2V617F(+) MPN.
Bone Cancer
Approved
| M.Wt | 404.3602 | |
| Formula | C17H21N6O4P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL; H2O: 5.4 mg/mL (Need ultrasonic or warming) |
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| Chemical Name/SMILES |
1H-Pyrazole-1-propanenitrile, .beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (.beta.R)-, phosphate (1:1) |
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1. Quintás-Cardama A, et al. Blood. 2010 Apr 15;115(15):3109-17.
2. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.
3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16;363(12):1117-27.
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