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Chemical Structure : Ryuvidine
CAS No.: 265312-55-8
Catalog No.: PC-62678Not For Human Use, Lab Use Only.
Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Ryuvidine (SPS8I-2) is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
Ryuvidine (SPS8I-2) shows potent cytototoxic activity against HL-60, A549, Col 1, HepG2 cancer cell lines with IC50 of 0.3-1.2 ug/mL.
Ryuvidine (SPS8I-2) also inhibits SETD8 with IC50 of 0.5 uM, efficiently and selectively suppresses cellular H4K20me1 at doses lower than 5 uM.
| M.Wt | 284.3 | |
| Formula | C15H12N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione |
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1. Blum G, et al. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.
2. Ryu CK, et al. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.
3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.
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