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S-230

Chemical Structure : S-230

CAS No.: 1254320-43-8

S-230 (OXE receptor antagonist S-230)

Catalog No.: PC-35314Not For Human Use, Lab Use Only.

OXE-R antagonist S-230 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor) with IC50 of 0.12 nM, inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils.

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    Biological Activity

    OXE-R antagonist S-230 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor) with IC50 of 0.12 nM, inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils.

    Physicochemical Properties

    M.Wt 377.909
    Formula C21H28ClNO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-5-(5-chloro-2-hexyl-1-methyl-1H-indol-3-yl)-3-methyl-5-oxopentanoic acid

    References

    1. Cossette C, et al. J Med Chem. 2016 Nov 23;59(22):10127-10146.

    2. Chourey S, et al. J Med Chem. 2018 Jul 4. doi: 10.1021/acs.jmedchem.8b00154.

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