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S-C025

Chemical Structure : S-C025

CAS No.: 2020058-34-6

S-C025 (OXE-R antagonist S-C025)

Catalog No.: PC-35313Not For Human Use, Lab Use Only.

S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM.
    S-C025 inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils.
    S-C025 is the highly potent OXE-R antagonists may provide a novel strategy for the treatment of eosinophilic disorders like asthma.

    Physicochemical Properties

    M.Wt 454.007
    Formula C27H32ClNO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-5-(5-chloro-1-methyl-2-(6-phenylhexyl)-1H-indol-3-yl)-3-methyl-5-oxopentanoic acid

    References

    1. Chourey S, et al. J Med Chem. 2018 Jul 4. doi: 10.1021/acs.jmedchem.8b00154.

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