S-C025 | OXE receptor antagonist | Probechem Biochemicals

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Chemical Structure : S-C025

S-C025 (OXE-R antagonist S-C025)

Catalog No.: PC-35313Not For Human Use, Lab Use Only.

S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor, OXE-R) with IC50 of 0.12 nM.
S-C025 inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils.
S-C025 is the highly potent OXE-R antagonists may provide a novel strategy for the treatment of eosinophilic disorders like asthma.

Physicochemical Properties

M.Wt	454.007
Formula	C27H32ClNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5-(5-chloro-1-methyl-2-(6-phenylhexyl)-1H-indol-3-yl)-3-methyl-5-oxopentanoic acid

References

1. Chourey S, et al. J Med Chem. 2018 Jul 4. doi: 10.1021/acs.jmedchem.8b00154.

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S-C025 (OXE-R antagonist S-C025)

Biological Activity

Physicochemical Properties

References

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