S1g-10 | Hsp70-Bim inhibitor | Probechem Biochemicals

Chemical Structure : S1g-10

S1g-10 (Hsp70-Bim PPI inhibitor)

Catalog No.: PC-22673Not For Human Use, Lab Use Only.

S1g-10 is a potent Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 688 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance in CML in vivo.

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Biological Activity

Physicochemical Properties

M.Wt	433.61
Formula	C26H31N3OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Phenalene-2-carbonitrile, 6-(cyclohexylthio)-3-[[2-(diethylamino)ethyl]amino]-1-oxo-

References

1. Wang Z, et al. J Med Chem. 2023 Dec 14;66(23):16377-16387.

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S1g-10 (Hsp70-Bim PPI inhibitor)

Biological Activity

Physicochemical Properties

References

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