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SA16

Chemical Structure : SA16

CAS No.: 1919884-11-9

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SA16 (Dual PDK1/Aurora A inhibitor SA16)

Catalog No.: PC-61110Not For Human Use, Lab Use Only.

SA16 is a potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SA16 is a potent, dual PDK1 and Aurora kinase A inhibitor with IC50 of 416 and 35 nM, respectively.
    SA16 blocks glioblastoma multiforme (GBM) proliferation with no toxicity in normal cells, induces GBM apoptosis and inhibits cell migration.
    SA16 exhibits an increased efficacy against glioma stem cells (GSCs), inducing their differentiation and apoptosis.

    Physicochemical Properties

    M.Wt 606.59
    Formula C33H24F2N6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R,Z)-N-(2-((3-((1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)amino)-2-oxo-1-phenylethyl)-1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

    References

    1. Daniele S, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114.

    2. Nagashima K, et al. J Biol Chem. 2011 Feb 25;286(8):6433-48.

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