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Chemical Structure : SA57
Catalog No.: PC-60706Not For Human Use, Lab Use Only.
SA57a is a highly potent and selective dual FAAH/MAGL inhibitor with IC50 of 1-3 nM against FAAH, inhibits mouse (IC50=410 nM) and human (IC50=1.4 uM) MAGL.
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SA57a is a highly potent and selective dual FAAH/MAGL inhibitor with IC50 of 1-3 nM against FAAH, inhibits mouse (IC50=410 nM) and human (IC50=1.4 uM) MAGL.
SA57 also inhibits the 2-AG hydrolases MAGL and ABHD6, but not other brain serine hydrolases.
SA57 produces antiwithdrawal effects in morphine-dependent mice, and does not elicit any cannabimimetic side effects.
| M.Wt | 338.832 | |
| Formula | C17H23ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Niphakis MJ, et al. ACS Chem Neurosci. 2012 May 16;3(5):418-26.
2. Ramesh D, et al. Neuropsychopharmacology. 2013 May;38(6):1039-49.
3. Wiebelhaus JM, et al. J Pharmacol Exp Ther. 2015 Feb;352(2):195-207.
4. Wilkerson JL, et al. Neuropharmacology. 2017 Mar 1;114:156-167.
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