Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : SACLAC
CAS No.: 2248703-42-4
Catalog No.: PC-72408Not For Human Use, Lab Use Only.
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
SACLAC induces apoptosis and loss of mitochondrial membrane potential, reduces cell viability and colony formation, reduces expression of SF3B1 and increases pro-apoptotic Mcl-1S.
SACLAC (5 mg/kg SACLAC in 45% w/v 2-hydroxypropyl-β-cyclodextrin in PBS) reduces leukemic burden in NSG mouse models of AML.
| M.Wt | 377.994 | |
| Formula | C20H40ClNO3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide |
|
1. Jennifer M Pearson, et al. Mol Cancer Res. 2020 Mar;18(3):352-363.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
