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Chemical Structure : SAFit1
CAS No.: 1643125-32-9
Catalog No.: PC-72576Not For Human Use, Lab Use Only.
SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote |
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SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52.
SAFit1 dose-dependently stimulates neurite outgrowth in primary hippocampal neurons derived from E18 mouse embryos.
SAFit1 showed antidepressant-like effects and partly prevented the inhibitory effects of dexamethasone on glucose uptake.
| M.Wt | 747.88 | |
| Formula | C42H53NO11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(3-((R)-1-((S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid |
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1. Gaali S, et al. Nat Chem Biol. 2015 Jan;11(1):33-7.
2. Sidibeh CO, et al. Endocrine. 2018 Oct;62(1):116-128.
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