SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52.
SAFit1 dose-dependently stimulates neurite outgrowth in primary hippocampal neurons derived from E18 mouse embryos.
SAFit1 showed antidepressant-like effects and partly prevented the inhibitory effects of dexamethasone on glucose uptake.
