SAL-0010003

Chemical Structure : SAL-0010003

Catalog No.: PC-23657Not For Human Use, Lab Use Only.

SAL-0010003 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 17.3 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 327 nM for 3D7 blood stage.

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Biological Activity

Physicochemical Properties

M.Wt	304.30
Formula	C15H14F2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2,4-difluorobenzyl)-3-isopropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

References

1. Gomez-Gonzalez PJ, et al. Sci Adv. 2024 Dec 6;10(49):eadq1383.

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SAL-0010003

Biological Activity

Physicochemical Properties

References

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