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SAL-0010042

Chemical Structure : SAL-0010042

CAS No.: 521298-46-4

SAL-0010042

Catalog No.: PC-23658Not For Human Use, Lab Use Only.

SAL-0010042 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 10.8 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 142 nM for 3D7 blood stage.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SAL-0010042 is a fast-acting and potent Plasmodium falciparum PDEβ inhibitor with IC50 of 10.8 nM for cGMP hydrolysis in crude gametocyte membrane preparations, and EC50 of 142 nM for 3D7 blood stage.

Physicochemical Properties

M.Wt 286.31
Formula C15H15FN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(2-fluorobenzyl)-3-isopropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

References

1. Gomez-Gonzalez PJ, et al. Sci Adv. 2024 Dec 6;10(49):eadq1383.

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