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SAN4825

Chemical Structure : SAN4825

CAS No.: 158020-72-5

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SAN4825 (SAN 4825)

Catalog No.: PC-20399Not For Human Use, Lab Use Only.

SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM.
    SAN4825 displays no significant activity agianst CD38 and A. californica ADPR cyclase.
    SAN4825 (3 uM) significantly reduced the number of delayed after depolarisations within 6 s following rapid pacing from 13.1 ± 2.7 to 2.9 ± 1.9.
    SAN4825 (3 mg/kg i.v.) significantly prolongs the time to ventrular fibrillation (VF) and cardiac arrest (CA) in vivo model of Ca2+ overload-induced ventricular arrhythmia.

    Physicochemical Properties

    M.Wt 361.36
    Formula C19H15N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((3-methyl-4-oxo-6-(pyridin-4-yl)-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)benzoic acid

    References

    1. Aimo Kannt, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):717-27.

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