SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM; displays no activity against a standard panel of 33 different receptors, channels, transporters and enzymes; inhibits human recombinant CN1 at a carnosine concentration of 200 µM with IC50 of 18 nM, also demonstrates inhibitory activity on human CN1 in serum from TG mice-expressing human CN1 and serum from healthy human volunteers with IC50 of 650 and 340 nM, respectively; increases carnosine levels in plasma and kidney in mice.
Physicochemical Properties
M.Wt
256.262
Formula
C10H16N4O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
((S)-4-amino-2-hydroxybutanoyl)-L-histidine
References
1. Qiu J, et al. Amino Acids. 2018 Jun 20. doi: 10.1007/s00726-018-2601-z.
