Chemical Structure : SANA
CAS No.:
42571-07-3
SANA
Catalog No.: PC-24788Not For Human Use, Lab Use Only.
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss.
SANA stimulates mitochondrial respiration, a gene expression signature of creatine-dependent thermogenesis and a UCP1-independent loss of weight.
SANA stimulates energy expenditure and protects against obesity under thermoneutral conditions.
SANA stimulates thermogenesis independently of UCP1 expression or activation and does not directly uncouple mitochondria.
SANA is effective for weight loss and weight gain prevention during DIO, but not under normal diet.
Physicochemical Properties
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M.Wt
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209.16
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Formula
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C9H7NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(2-nitroethenyl)salicylic acid
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References
1. Cal K, et al. Nat Metab. 2025 Jun 17. doi: 10.1038/s42255-025-01311-z.
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