Catalog No.: PC-35842Not For Human Use, Lab Use Only.
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM).
SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM).
SAR-20347 potently inhibits IL-12-mediated STAT4 phosphorylation with IC50 of 126 nM.
SAR-20347 inhibits JAK1-mediated IL-6 pSTAT3 signaling with IC50 of 345 nM in TF-1 and 407 nM in CD4+ cells, poorly inhibits JAK2 mediated STAT5 phosphorylation with IC50 of >1 uM.
SAR-20347 ameliorates imiquimod-induced psoriasis-like dermatitis in vivo.
