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SAR216471 hydrochloride

Chemical Structure : SAR216471 hydrochloride

CAS No.: 1279829-64-9

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SAR216471 hydrochloride (SAR-216471 hydrochloride)

Catalog No.: PC-61535Not For Human Use, Lab Use Only.

SAR216471 hydrochloride is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SAR216471 hydrochloride is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM.
    SAR216471 inhibits ADP-induced platelet aggregation in human platelet rich plasma with IC50 of 0.1 uM.
    SAR216471 exhibits an ED50 of 2.75mg/kg in ex vivo platelet aggregation model in rats.

    Physicochemical Properties

    M.Wt 599.51
    Formula C28H31ClN8O3.HCl
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(6-(4-butyryl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl)-5-chloro-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-1H-indole-3-carboxamide hydrochloride

    References

    1. Boldron C, et al. J Med Chem. 2014 Sep 11;57(17):7293-316.

    2. Delesque-Touchard N, et al. Thromb Res. 2014 Sep;134(3):693-703.

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