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Chemical Structure : SAR7334
CAS No.: 1333210-07-3
Catalog No.: PC-20743Not For Human Use, Lab Use Only.
SAR7334 (SAR-7334 ) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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SAR7334 (SAR-7334 ) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM.
SAR7334 also inhibits TRPC3 and TRPC7 channels at significantly higher concentrations (IC50=282 nM and 226 nM respectively), has no appreciable effects on TRPC4 or TRPC5 channels (IC50>10 uM).
SAR7334 dose-dependently reduces TRPC6 currents in patch-clamp experiments on TRPC6-HEK-FITR cells with IC50 of 7.9 nM.
SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice, does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
| M.Wt | 367.88 | |
| Formula | C21H22ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile |
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1. Maier T, et al. Br J Pharmacol. 2015 Jul;172(14):3650-60.
2. Chauvet S, et al. Front Pharmacol. 2016 Dec 12;7:486.
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