Chemical Structure : SARM1 inhibitor 19
CAS No.:
SARM1 inhibitor 19
Catalog No.: PC-26502Not For Human Use, Lab Use Only.
SARM1 inhibitor 19 is a potent, selective and orally bioavailable SARM1 inhibitor with pIC50 of 7.1 (hSARM1), protect primary rat and mouse DRGs treated with vincristine with EC50 of 55 nM and 113 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SARM1 inhibitor 19 is a potent, selective and orally bioavailable SARM1 inhibitor with pIC50 of 7.1 (hSARM1), protect primary rat and mouse DRGs treated with vincristine with EC50 of 55 nM and 113 nM respectively.
SARM1 inhibitor 19 binds at the interfaces of neighboring TIR subunits in the double-stranded assembly traps the enzyme in a state poised for activity while blocking the active sites.
SARM1 inhibitor 19 exacerbates neuronal degeneration and cell death in vitro.
SARM1 inhibitor 19 exhibits dose-dependent efficacy and subinhibitory effect in a mouse SNI model.
Physicochemical Properties
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M.Wt
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454.51
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Formula
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C25H23FN8
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(7-((2-(Dimethylamino)ethyl)amino)-1-methyl-2-(pyridin-4-yl)-1H-imidazo[4,5-c]pyridin-6-yl)-6-fluoro-1H-indole-4-carbonitrile
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References
1. Albanese SK, et al. J Med Chem. 2026 Apr 8. doi: 10.1021/acs.jmedchem.6c00352.
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