SARM1 inhibitor NB-3 | SARM1 inhibitor

Chemical Structure : SARM1 inhibitor NB-3

CAS No.:

SARM1 inhibitor NB-3 (NB3)

Catalog No.: PC-49319Not For Human Use, Lab Use Only.

SARM1 inhibitor NB-3 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.195 uM, and IC50 of 0.08 uM in SARM-induced cell-death rescue assays.

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Biological Activity

SARM1 inhibitor NB-3 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.195 uM, and IC50 of 0.08 uM in SARM-induced cell-death rescue assays.

SARM1 inhibitor NB-3 targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).

SARM1 inhibitor NB-3 is highly potent and confer compelling neuroprotection in preclinical models of neurological injury and disease.

NB-3 does not inhibit the most closely related NAD hydrolase, CD38, and a panel of Sirtuins and PARPs (IC50 > 50 μM)

NB-3 lowers plasma NfL and improves functional outcomes in preclinical models of nerve injury and neuropathy.

NB-3 attenuates neurodegeneration decline in preclinical models of chemotherapy-induced peripheral neuropathy (CIPN).

Physicochemical Properties

M.Wt	261.248
Formula	C11H14F3N3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-methyl-1-(1-(pyridin-4-yl)ethyl)-3-(2,2,2-trifluoroethyl)urea

References

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

SARM1 inhibitor NB-3 (NB3)

Biological Activity

Physicochemical Properties

References

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