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SARM1 inhibitor NB-3

Chemical Structure : SARM1 inhibitor NB-3

CAS No.:

SARM1 inhibitor NB-3 (NB-3)

Catalog No.: PC-49319Not For Human Use, Lab Use Only.

SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).

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Biological Activity

SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).
SARM1 inhibitor NB-3 is highly potent and confer compelling neuroprotection in preclinical models of neurological injury and disease.

Physicochemical Properties

M.Wt 261.248
Formula C11H14F3N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-methyl-1-(1-(pyridin-4-yl)ethyl)-3-(2,2,2-trifluoroethyl)urea

References

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

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