SARM1 inhibitor NB-7 | SARM1 inhibitor

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Chemical Structure : SARM1 inhibitor NB-7

SARM1 inhibitor NB-7 (NB7)

Catalog No.: PC-24261Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SARM1 inhibitor NB-7 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.025 uM, and IC50 of 0.008 uM in SARM-induced cell-death rescue assays.
NB-7 potently protectes against axon degeneration with IC50 of 0.11 uM in cellular models of nerve injury.

Physicochemical Properties

M.Wt	340.81
Formula	C18H17ClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-N-(4-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

References

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

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SARM1 inhibitor NB-7 (NB7)

Biological Activity

Physicochemical Properties

References

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