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SARS-CoV-2 Mpro inhibitor 11b

Chemical Structure : SARS-CoV-2 Mpro inhibitor 11b

CAS No.: 2413716-71-7

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SARS-CoV-2 Mpro inhibitor 11b

Catalog No.: PC-72202Not For Human Use, Lab Use Only.

SARS-CoV-2 Mpro inhibitor 11b is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 40 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SARS-CoV-2 Mpro inhibitor 11b is a potent, selective SARS-CoV-2 Mpro inhibitor with IC50 of 40 nM.
    Mpro inhibitor 11b exhibited good anti-SARS-CoV-2-infection activity in cell culture with EC50 value 0.72 uM using plaque-reduction assay, without significant cytotoxicity (CC50>100 uM).
    Mpro inhibitor 11b covalently bound to cysteine 145 of Mpro, showed good pharmacokinetic properties in vivo.

    Physicochemical Properties

    M.Wt 464.497
    Formula C25H25FN4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((S)-3-(3-fluorophenyl)-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2- yl)amino)propan-2-yl)-1H-indole-2-carboxamide

    References

    1. Wenhao Dai, et al. Science. 2020 Jun 19;368(6497):1331-1335.

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