Chemical Structure : SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2
CAS No.:
SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2
(SW090466, NiRAN covalent inhibitor 2)
Catalog No.: PC-23595Not For Human Use, Lab Use Only.
NCI-2 is a small molecule inhibitor of SARS-CoV-2 nsp12 NiRAN domain, covalently binds to an active site cysteine (Cys53) in the NiRAN domain, inhibiting nsp12-dependent AMPylation of nsp9 with IC50 of 4.3 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NCI-2 is a small molecule inhibitor of SARS-CoV-2 nsp12 NiRAN domain, covalently binds to an active site cysteine (Cys53) in the NiRAN domain, inhibiting nsp12-dependent AMPylation of nsp9 with IC50 of 4.3 uM.
NCI-2 can enter cells, bind to, and inactivate ectopically expressed nsp12.
NCI-2 shows inhibition of NiRAN-dependent RNAylation of nsp9 and an increase in the thermal stability of nsp12.
NCI-2 demonstrates limited potency in inhibiting SARS-CoV-2 replication (IC50=200 uM).
Physicochemical Properties
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M.Wt
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240.64
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Formula
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C10H9ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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methyl 5-(chloromethyl)-7-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate
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References
1. Hernandez G, et al. bioRxiv [Preprint]. 2024 Nov 25:2024.11.22.624893.
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