Catalog No.: PC-38498Not For Human Use, Lab Use Only.
SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
SARS-CoV-2 nsp14 N7-MTase catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine (SAM) cofactor to the N7-guanosine cap, which is essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity.
