Catalog No.: PC-21121Not For Human Use, Lab Use Only.
SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist, potently displaces [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT6 receptors recombinantly expressed in HeLa cells with pKi 8.92 and 9.09 respectively.
SB-271046 is a potent, selective and orally active 5-HT6 receptor antagonist, potently displaces [(3)H]-LSD and [(125)I]-SB-258585 from human 5-HT6 receptors recombinantly expressed in HeLa cells with pKi 8.92 and 9.09 respectively.
SB-271046 also displaces [(125)I]-SB-258585 from human caudate putamen and rat and pig striatum membranes (pK(i) 8.81, 9.02 and 8.55 respectively).
SB-271046 is >200 fold selective for the 5-HT(6) receptor vs. 55 other receptors, binding sites and ion channels.
SB-271046 competitively antagonizes 5-HT-induced stimulation of adenylyl cyclase activity with a pA(2) of 8.71 in functional studies on human 5-HT(6) receptors.
SB-271046 (10 mg/kg) demonstrates anticonvulsant activity in the rat MEST test.
