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SB-277011

Chemical Structure : SB-277011

CAS No.: 215803-78-4

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SB-277011 (SB277011A, SB277011)

Catalog No.: PC-42716Not For Human Use, Lab Use Only.

SB-277011 (SB277011A) is a potent and selective dopamine D3 receptor antagonist with pKi of 8.0.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SB-277011 (SB277011A) is a potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
SB-277011 displays >100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors.
SB-277011 exhibits high oral bioavailability and brain penetration in rats.

Physicochemical Properties

M.Wt 438.564
Formula C28H30N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-

References

1. Stemp G, et al. J Med Chem. 2000 May 4;43(9):1878-85.

2. Reavill C, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65.

3. Ashby CR Jr, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1166-74.

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