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Chemical Structure : SB-277011
Catalog No.: PC-42716Not For Human Use, Lab Use Only.
SB-277011 (SB277011A) is a potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
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SB-277011 (SB277011A) is a potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
SB-277011 displays >100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors.
SB-277011 exhibits high oral bioavailability and brain penetration in rats.
| M.Wt | 438.564 | |
| Formula | C28H30N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stemp G, et al. J Med Chem. 2000 May 4;43(9):1878-85.
2. Reavill C, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65.
3. Ashby CR Jr, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1166-74.
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