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SB-423557

Chemical Structure : SB-423557

CAS No.: 351490-26-1

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SB-423557 (SB423557)

Catalog No.: PC-26411Not For Human Use, Lab Use Only.

SB-423557 is the orally bioavailable ethyl ester precursor of SB-423562, which is a potent, selective and short-acting calcium-sensing receptor (CaSR) antagonist with IC50 of 73 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SB-423557 is the orally bioavailable ethyl ester precursor of SB-423562, which is a potent, selective and short-acting calcium-sensing receptor (CaSR) antagonist with IC50 of 73 nM.
SB-423557 exhibits CaSR antagonist activity in vitro with IC50 of 520 nM.
SB-423557 elicits transient PTH release from the parathyroid gland.
SB-423557 promoted bone formation and improved parameters of bone strength at lumbar spine, proximal tibia and midshaft femur in ovariectomized rat model of bone loss.

Physicochemical Properties

M.Wt 464.61
Formula C28H36N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl (R)-3-(4-cyano-3-(3-((1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)phenyl)propanoate

References

1. Sanjay Kumar, et al. Bone. 2010 Feb;46(2):534-42.

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