Chemical Structure : SB-435495
CAS No.:
304694-39-1
SB-435495
(SB435495)
Catalog No. : PC-63003Not For Human Use, Lab Use Only.
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
Packing Price Stock Quantity 5 mg $138 In stock 0 1 2 3 4 5 10 mg $218 In stock 0 1 2 3 4 5 25 mg $368 In stock 0 1 2 3 4 5 50 mg Get quote 0 1 2 3 4 5 100 mg Get quote 0 1 2 3 4 5
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6300301
Biological Activity
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
Physicochemical Properties
M.Wt
720.832
Formula
C38H40F4N6O2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1(4H)-Pyrimidineacetamide, N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-
References
1. Blackie JA, et al. Bioorg Med Chem Lett.
2. Canning P, et al. Proc Natl Acad Sci U S A.
3. Tyurin VA, et al. Cell Death Differ
4. Jiang Z, et al. Respir Res
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