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Chemical Structure : SB27012
Catalog No.: PC-38235Not For Human Use, Lab Use Only.
SB27012 (SB 27012) is a small molecule PPI inhibitor of the Spike RBD-ACE2 interaction (IC50=7.7 uM in ELISA assays), binds ACE2 (Kd=210 nM) without affecting ACE2 enzymatic activity.
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SB27012 (SB 27012) is a small molecule PPI inhibitor of the Spike RBD-ACE2 interaction (IC50=7.7 uM in ELISA assays), binds ACE2 (Kd=210 nM) without affecting ACE2 enzymatic activity.
Using a sandwich ELISA-based screening using the plate-bound RBD (Arg319-Phe541) and extracellular domain of human ACE2 (Gln18-Ser740), SB27012 was identified and affinity determinated.
SB27012 inhibits the ACE2-spike interaction by inducing allosteric changes in ACE2.
SB27012 blocked the SARS-CoV-2 spread with IC50 of 3.3 uM.
SB27012 reduced infection predominantly at early time points, suggesting that SB27012 blocked the entry step of viral infection.
| M.Wt | 602.739 | |
| Formula | C36H38N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Young-Hee Shin, et al. Angew Chem Int Ed Engl. 2022 Jan 18;e202115695.
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