SBI-183 is a small molecule that binds to and inhibits the enzymatic activity of Quiescin sulfhydryl oxidase 1 (QSOX1, Kd=20 uM).
SBI-183 inhibits proliferation of tumor cells, but does not kill fibroblasts or rapidly proliferating PBMC, inhibits viability of 786-O, RCJ-41T2, and MDA-MB-231 with IC50 of 4.6 μM, 3.9 μM, and 2.4 μM respectively.
Oral administration of SBI-183 inhibits tumor growth in 2 independent human xenograft mouse models of renal cell carcinoma.
Physicochemical Properties
M.Wt
296.37
Formula
C18H20N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]benzamide
References
1. Paul D Hanavan, et al. Oncotarget. 2015 Jul 30;6(21):18418-28.
2. Amber L Fifield, et al. Mol Cancer Ther. 2020 Jan;19(1):112-122.
