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Chemical Structure : SBI-183
CAS No.: 625403-59-0
Catalog No.: PC-38165Not For Human Use, Lab Use Only.
SBI-183 is a small molecule that binds to and inhibits the enzymatic activity of Quiescin sulfhydryl oxidase 1 (QSOX1, Kd=20 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SBI-183 is a small molecule that binds to and inhibits the enzymatic activity of Quiescin sulfhydryl oxidase 1 (QSOX1, Kd=20 uM).
SBI-183 inhibits proliferation of tumor cells, but does not kill fibroblasts or rapidly proliferating PBMC, inhibits viability of 786-O, RCJ-41T2, and MDA-MB-231 with IC50 of 4.6 μM, 3.9 μM, and 2.4 μM respectively.
Oral administration of SBI-183 inhibits tumor growth in 2 independent human xenograft mouse models of renal cell carcinoma.
| M.Wt | 296.37 | |
| Formula | C18H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]benzamide |
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1. Paul D Hanavan, et al. Oncotarget. 2015 Jul 30;6(21):18418-28.
2. Amber L Fifield, et al. Mol Cancer Ther. 2020 Jan;19(1):112-122.
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