SBI-221 | SHP2-E76K inhibitor | Probechem Biochemicals

Chemical Structure : SBI-221

SBI-221 (SBI 221)

Catalog No.: PC-20711Not For Human Use, Lab Use Only.

SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively.

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Biological Activity

SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively.

Physicochemical Properties

M.Wt	513.41
Formula	C24H13F6N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)-4-(trifluoromethyl)-6-(6-(trifluoromethyl)pyridin-3-yl)pyrimidine

References

1. Romero C, et al. J Biol Chem. 2020 Feb 28;295(9):2601-2613.

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SBI-221 (SBI 221)

Biological Activity

Physicochemical Properties

References

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