SBI-2771

Chemical Structure : SBI-2771

Catalog No.: PC-28529Not For Human Use, Lab Use Only.

SBI-2771 is a small-molecule inhibitor of the Tau-LRP1 (low-density lipoprotein receptor-related protein 1) interaction with IC50 of 4.5 uM in LRP1-BD4-L57 TR-FRET assay, reduces tau uptake in H4 neuroglioma cells.

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Biological Activity

Physicochemical Properties

M.Wt	390.13
Formula	C11H5Cl2F4N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dichlorophenyl)-3-(5-fluoro-4-oxo-5-(trifluoromethyl)-4,5-dihydrothiazol-2-yl)urea

References

1. Wang C, et al. ACS Chem Biol. 2026 Oct 13. doi: 10.1021/acschembio.6c00599.

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SBI-2771

Biological Activity

Physicochemical Properties

References

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