Chemical Structure : SBI-477
CAS No.: 781628-99-7
Catalog No.: PC-61673Not For Human Use, Lab Use Only.
SBI-477 is a chemical probe that coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes with EC50 of 100 nM and 1 uM, respectively.
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SBI-477 is a chemical probe that coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes with EC50 of 100 nM and 1 uM, respectively.
SBI-477 reduces expression of TXNIP and ARRDC4, negative regulators of insulin signaling, via deactivation of the transcription factor MondoA.
M.Wt | 483.539 | |
Formula | C24H25N3O6S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3-methoxy-N-(4-(4-methoxyphenyl)thiazol-2-yl)-4-(2-morpholino-2-oxoethoxy)benzamide |
1. Ahn B, et al. J Clin Invest. 2016 Sep 1;126(9):3567-79.
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