Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-SBI-581
SBI-581

Chemical Structure : SBI-581

CAS No.:

Add to Favorites

SBI-581 (SBI 581)

Catalog No.: PC-72447Not For Human Use, Lab Use Only.

SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.
    SBI-581 showed moderate selectivity against a broad panel of kinases (MEKK3 IC50=237 nM), and displayed reasonable PK after i.p. injection.
    SBI-581 treatment reduces invadopodia function, 3D growth, and extravasation in vitro and in vivo, promoted TKS5α accumulation at RAB11-positive vesicles;.
    SBI-581 exerted its effects through preventing TAO3 phosphorylation of dynein subunit protein LIC2 on S202.

    Physicochemical Properties

    M.Wt 383.451
    Formula C24H21N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-3-((1H-indol-2-yl)methylene)-4-((4-hydroxypiperidin-4-yl)ethynyl)indolin-2-one

    References

    1. Shinji Iizuka, et al. Cancer Res. 2021 Mar 15;81(6):1472-1485.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: