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SBI-581

Chemical Structure : SBI-581

CAS No.:

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SBI-581 (SBI 581)

Catalog No.: PC-72447Not For Human Use, Lab Use Only.

SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SBI-581 (SBI 581) is a potent, selective inhibitor of serine-threonine kinase TAO3 with IC50 of 42 nM, an STE20-like kinase of the GCK subfamily.
    SBI-581 showed moderate selectivity against a broad panel of kinases (MEKK3 IC50=237 nM), and displayed reasonable PK after i.p. injection.
    SBI-581 treatment reduces invadopodia function, 3D growth, and extravasation in vitro and in vivo, promoted TKS5α accumulation at RAB11-positive vesicles;.
    SBI-581 exerted its effects through preventing TAO3 phosphorylation of dynein subunit protein LIC2 on S202.

    Physicochemical Properties

    M.Wt 383.451
    Formula C24H21N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-3-((1H-indol-2-yl)methylene)-4-((4-hydroxypiperidin-4-yl)ethynyl)indolin-2-one

    References

    1. Shinji Iizuka, et al. Cancer Res. 2021 Mar 15;81(6):1472-1485.

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