SC-66 |CAS:871361-88-5 Probechem Biochemicals

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Chemical Structure : SC-66

CAS No.: 871361-88-5

SC-66 (SC66;SC 66)

Catalog No.: PC-45738Not For Human Use, Lab Use Only.

SC66 is an allosteric Akt inhibitor, exhibits a dual inhibitory activity that directly interferes with the PH domain binding to PIP3 and facilitates Akt ubiquitination.

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10 mg	$78	In stock
25 mg	$118	In stock
50 mg	$188	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SC66 is an allosteric Akt inhibitor, exhibits a dual inhibitory activity that directly interferes with the PH domain binding to PIP3 and facilitates Akt ubiquitination.
SC66 has anticancer activity mouse xenograft tumor model.

Physicochemical Properties

M.Wt	276.3324
Formula	C18H16N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 34 mg/mL
Chemical Name/SMILES	Cyclohexanone, 2,6-bis(4-pyridinylmethylene)-, (2E,6E)-

References

1. Jo H, et al. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91.

2. Cusimano A, et al. Oncotarget. 2015 Jan 30;6(3):1707-22.

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SC-66 (SC66;SC 66)

Biological Activity

Physicochemical Properties

References

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