Chemical Structure : SC57461A
CAS No.: 423169-68-0
Catalog No.: PC-70334Not For Human Use, Lab Use Only.
SC57461A (SC 57461A) is a potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM.
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SC57461A (SC 57461A) is a potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM.
SC57461A (SC 57461A) inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
SC57461A (SC 57461A) has no effect on production of the cyclooxygenase metabolite thromboxane B(2).
SC57461A (SC 57461A) is orally active in vivo.
M.Wt | 363.88 | |
Formula | C20H25NO3.HCl | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride |
1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82.
2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.
3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.
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