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SC57461A

Chemical Structure : SC57461A

CAS No.: 423169-68-0

SC57461A (SC 57461A, SC-57461A)

Catalog No.: PC-70334Not For Human Use, Lab Use Only.

SC57461A (SC 57461A) is a potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SC57461A (SC 57461A) is a potent and selective inhibitor of LTA4 hydrolase (LTA4H) with IC50/Ki of 5 nM/23 nM.
SC57461A (SC 57461A) inhibits calcium ionophore-induced LTB(4) production in human whole blood (IC50=49 nM).
SC57461A (SC 57461A) has no effect on production of the cyclooxygenase metabolite thromboxane B(2).
SC57461A (SC 57461A) is orally active in vivo.

Physicochemical Properties

M.Wt 363.88
Formula C20H25NO3.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-((3-(4-benzylphenoxy)propyl)(methyl)amino)propanoic acid hydrochloride

References

1. Askonas LJ, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):577-82.

2. Kachur JF, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):583-7.

3. Penning TD, et al. J Med Chem. 2002 Aug 1;45(16):3482-90.

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