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Chemical Structure : SCH-1473759
Catalog No.: PC-42611Not For Human Use, Lab Use Only.
SCH-1473759 is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
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SCH-1473759 is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
SCH-1473759 shows improved cell potency (phos-HH3 inhibition IC50=25 nM) and intrinsic aqueous solubility (11.4 mM).
SCH-1473759 demonstrated efficacy and target engagement in human tumor xenograft mouse models.
| M.Wt | 426.5385 | |
| Formula | C20H26N8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yu T, et al. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.
2. Basso AD, et al. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.
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