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SCH-1473759 hydrochloride

Chemical Structure : SCH-1473759 hydrochloride

CAS No.: 1094067-13-6

SCH-1473759 hydrochloride (SCH1473759 hydrochloride)

Catalog No.: PC-42612Not For Human Use, Lab Use Only.

SCH-1473759 hydrochloride is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SCH-1473759 hydrochloride is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
SCH-1473759 shows improved cell potency (phos-HH3 inhibition IC50=25 nM) and intrinsic aqueous solubility (11.4 mM)。
SCH-1473759 emonstrated efficacy and target engagement in human tumor xenograft mouse models.

Physicochemical Properties

M.Wt 462.9994
Formula C20H27ClN8OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO

Chemical Name/SMILES

1-Propanol, 2-[ethyl[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]amino]-2-methyl-, hydrochloride (1:x)

References

1. Yu T, et al. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.

2. Basso AD, et al. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.

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