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Chemical Structure : SCH-1473759 hydrochloride
CAS No.: 1094067-13-6
Catalog No.: PC-42612Not For Human Use, Lab Use Only.
SCH-1473759 hydrochloride is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $168 | In stock | |
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | Get quote | ||
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SCH-1473759 hydrochloride is a potent, picomolar, dual inhibitor of Aurora A and Aurora B with IC50 of 0.02 and 0.03 nM, respectively.
SCH-1473759 shows improved cell potency (phos-HH3 inhibition IC50=25 nM) and intrinsic aqueous solubility (11.4 mM)。
SCH-1473759 emonstrated efficacy and target engagement in human tumor xenograft mouse models.
| M.Wt | 462.9994 | |
| Formula | C20H27ClN8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
1-Propanol, 2-[ethyl[[5-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-isothiazolyl]methyl]amino]-2-methyl-, hydrochloride (1:x) |
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1. Yu T, et al. ACS Med Chem Lett. 2010 Jun 7;1(5):214-8.
2. Basso AD, et al. Cancer Chemother Pharmacol. 2011 Oct;68(4):923-33.
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