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SCH-479833

Chemical Structure : SCH-479833

CAS No.: 473725-29-0

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SCH-479833 (SCH479833)

Catalog No.: PC-20802Not For Human Use, Lab Use Only.

SCH-479833 is a potent, specific and orally active CXCR1 and CXCR2 antagonist with Ki of 0.17 and 7 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SCH-479833 is a potent, specific and orally active CXCR1 and CXCR2 antagonist with Ki of 0.17 and 7 nM, respectively.
    SCH-479833 inhibits microvessel density in human melanoma tumors, inhibits melanoma cell motility and invasion.
    SCH-479833 inhibits A375SM cell proliferation and ERK1/2 signaling.
    SCH-479833 (100 mg/kg, i.p.) inhibits proliferation and survival in human melanoma tumor mice model.

    Physicochemical Properties

    M.Wt 393.44
    Formula C22H23N3O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    O=C(N(C)C)C1=CC=CC(NC2=C(N[C@@H](C3=CC=CC=C3)CC)C(C2=O)=O)=C1O

    References

    1. Singh S, et al. Clin Cancer Res. 2009 Apr 1;15(7):2380-6.

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