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SCH-563705

Chemical Structure : SCH-563705

CAS No.: 473728-58-4

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SCH-563705 (SCH563705)

Catalog No.: PC-42055Not For Human Use, Lab Use Only.

SCH-563705 is a potent, orally bioavailable dual CXCR2/CXCR1 receptor antagonist with IC50 of 1.3 nM and 7.3 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SCH-563705 is a potent, orally bioavailable dual CXCR2/CXCR1 receptor antagonist with IC50 of 1.3 nM and 7.3 nM, respectively.
SCH-563705 demonstrates potent inhibition against both Gro-alpha and IL-8 induced hPMN migration (Chemotaxis: CXCR2 IC50=0.5 nM, CXCR1 IC50=37 nM).
SCH-563705 dose-dependently decreases paw thickness and clearly reduces inflammation, and bone and cartilage degradation in a mouse model of arthritis.

Physicochemical Properties

M.Wt 425.4776
Formula C23H27N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥30mg/mL
Chemical Name/SMILES

Benzamide, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-[4-(1-methylethyl)-2-furanyl]propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-

References

1. Chao J, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3778-83.

2. Min SH, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):1080-6.

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