Catalog No.: PC-22147Not For Human Use, Lab Use Only.
SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH23390 shows high affinity to human 5-HT2C receptor with a Ki of 9.3 nM, also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH23390 inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel with IC50 of 268 nM. SCH23390 (1 uM) reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH23390 abolishes generalized seizures evoked by the chemoconvulsants.
