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Chemical Structure : SCH23390 hydrochloride
CAS No.: 125941-87-9
Catalog No.: PC-22147Not For Human Use, Lab Use Only.
SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
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|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
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SCH23390 hydrochloride is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively.
SCH23390 shows high affinity to human 5-HT2C receptor with a Ki of 9.3 nM, also binds with high affinity to the 5-HT2 and 5-HT1C receptors.
SCH23390 inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel with IC50 of 268 nM.
SCH23390 (1 uM) reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells.
SCH23390 abolishes generalized seizures evoked by the chemoconvulsants.
| M.Wt | 324.25 | |
| Formula | C17H19Cl2NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride |
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1. Bourne JA, et al. CNS Drug Rev. 2001 Winter;7(4):399-414.
2. Millan MJ, et al. Psychopharmacology (Berl). 2001 Jun;156(1):58-62.
3. Kuzhikandathil EV, et al. Mol Pharmacol. 2002 Jul;62(1):119-26.
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