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SCH 412348

Chemical Structure : SCH 412348

CAS No.: 377727-26-9

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SCH 412348 (SCH412348)

Catalog No.: PC-63020Not For Human Use, Lab Use Only.

SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM.
    SCH 412348 has >1000-fold selectivity over all other adenosine receptors.
    SCH 412348 attenuates hypolocomotion induced by the A2AR agonist CGS-21680.
    SCH 412348 exhibits antidepressant-like profiles in models of behavioral despair.

    Physicochemical Properties

    M.Wt 465.469
    Formula C22H21F2N9O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-[2-[4-(2,4-Difluorophenyl)-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine

    References

    1. Neustadt BR, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):967-71.

    2. Smith KM, et al. Eur J Pharmacol. 2014 Apr 5;728:31-8.

    3. Grauer SM, et al. Psychopharmacology (Berl). 2014 Apr;231(7):1325-37.

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