SCH 529074 |CAS:922150-11-6 Probechem Biochemicals

Chemical Structure : SCH 529074

CAS No.: 922150-11-6

SCH 529074 (SCH529074)

Catalog No.: PC-62084Not For Human Use, Lab Use Only.

SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM.

Packing	Price	Stock
5 mg	$178	In stock
10 mg	$298	In stock
25 mg	$498	In stock
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Biological Activity

SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM.
SCH 529074 restores growth-suppressive function to mutant p53 and inhibits ubiquitination of p53 by HDM2.

Physicochemical Properties

M.Wt	563.6
Formula	C31H36Cl2N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine

References

1. Demma M, et al. J Biol Chem. 2010 Apr 2;285(14):10198-212.

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SCH 529074 (SCH529074)

Biological Activity

Physicochemical Properties

References

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