Catalog No.: PC-73066Not For Human Use, Lab Use Only.
SCO-792 (SCO792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.
Sucunamostat (SCO-792, TAK792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.
SCO-792 displayed high selectivity against other serine proteases, showed < 50% inhibitory activity against chymotrypsin, DPP‐4, factor XIIa, factor Xa, and thrombin at 10 uM.
SCO-792 inhibited plasma kallikrein with an IC50 value of 16 nM and plasmin with an IC50 value of 460 nM , also inhibited trypsin with an IC50 value of 3.3 nM.
SCO-792 effectively and dose‐dependently inhibited plasma BCAA elevations induced by oral protein dosing in rats.
