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SCO-792

Chemical Structure : SCO-792

CAS No.: 1802888-04-5

SCO-792 (Sucunamostat, SCO792, TAK792)

Catalog No.: PC-73066Not For Human Use, Lab Use Only.

SCO-792 (SCO792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.

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Biological Activity

Sucunamostat (SCO-792, TAK792) is a potent, selective, reversible enteropeptidase inhibitor with IC50 of 4.6 and 5.4 nM for rat and human enteropeptidase, respectively.
SCO-792 displayed high selectivity against other serine proteases, showed < 50% inhibitory activity against chymotrypsin, DPP‐4, factor XIIa, factor Xa, and thrombin at 10 uM.
SCO‐792 inhibited plasma kallikrein with an IC50 value of 16 nM and plasmin with an IC50 value of 460 nM , also inhibited trypsin with an IC50 value of 3.3 nM.
SCO‐792 effectively and dose‐dependently inhibited plasma BCAA elevations induced by oral protein dosing in rats.

Physicochemical Properties

M.Wt 470.43
Formula C22H22N4O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

((S)-6-((4-guanidinobenzoyl)oxy)-2,3-dihydrobenzofuran-3-carbonyl)-L-aspartic acid hydrate

References

1. Yashiro H, et al. Diabetes Obes Metab. 2019 Oct;21(10):2228-2239.

2. Sasaki M, et al. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517.

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