SCYX-7158 |Cas:1266084-51-8 Buy SCYX-7158 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : SCYX-7158

CAS No.: 1266084-51-8

SCYX-7158 (AN-5568;SCYX 7158;AN 5568;Acoziborole)

Catalog No.: PC-60316Not For Human Use, Lab Use Only.

SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.

Packing	Price	Stock
5 mg	$298	In stock
10 mg	$488	In stock
25 mg	$758	In stock
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Biological Activity

SCYX-7158 (AN-5568, Acoziborole) is an orally-active, CNS permeable benzoxaborole antiprotozoal agent.
SCYX-7158 is active in vitro against relevant strains of Trypanosoma brucei, including T. b. rhodesiense and T. b. gambiense.
SCYX-7158 is efficacious in both stage 1 and stage 2 murine HAT models and has good physicochemical and ADMET properties for the treatment of stage 2 human African trypanosomiasis.

Physicochemical Properties

M.Wt	367.102
Formula	C17H14BF4NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-(trifluoromethyl)benzamide

References

1. Jacobs RT, et al. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151.

2. Jacobs RT, et al. Future Med Chem. 2011 Aug;3(10):1259-78.

3. Wring S, et al. Parasitology. 2014 Jan;141(1):104-18.

SCYX-7158 (AN-5568;SCYX 7158;AN 5568;Acoziborole)

Biological Activity

Physicochemical Properties

References

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