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SD-066-4

Chemical Structure : SD-066-4

CAS No.: 64640-77-3

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SD-066-4 (ZDHHC20 inhibitor SD-066-4)

Catalog No.: PC-22842Not For Human Use, Lab Use Only.

SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.
SD-066-4 shows high selectivity for ZDHHC20, without effect on ZDHHC23.
SD-066-4 reduces EGFR S-acylation in Kras mutant cells and blocks the growth of Kras mutant lung tumors extending overall survival.
A specific alanine residue (alanine 144) accommodates the methyl group of SD-066-4, thus providing isoform selectivity.

Physicochemical Properties

M.Wt 273.34
Formula C18H15N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(5-(p-tolyl)-1H-pyrazol-3-yl)-1H-indole

References

1. Lee JY, et al. bioRxiv [Preprint]. 2024 Jul 22:2024.07.18.604152.

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