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Chemical Structure : SD-066-4
Catalog No.: PC-22842Not For Human Use, Lab Use Only.
SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.
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SD-066-4 is a selective inhibitor of S-acyltransferase ZDHHC20 (Zinc Finger DHHC-Type Palmitoyltransferase 20), inhibits EGFR S-acylation at concentrations as low as 1 uM.
SD-066-4 shows high selectivity for ZDHHC20, without effect on ZDHHC23.
SD-066-4 reduces EGFR S-acylation in Kras mutant cells and blocks the growth of Kras mutant lung tumors extending overall survival.
A specific alanine residue (alanine 144) accommodates the methyl group of SD-066-4, thus providing isoform selectivity.
| M.Wt | 273.34 | |
| Formula | C18H15N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee JY, et al. bioRxiv [Preprint]. 2024 Jul 22:2024.07.18.604152.
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