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SD-70

Chemical Structure : SD-70

CAS No.: 332173-89-4

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SD-70 (SD70, KDM4C inhibitor)

Catalog No.: PC-70332Not For Human Use, Lab Use Only.

SD-70 is a small molecule tumor translocation inhibitor that inhibits the prostate cancer cell transcriptional program, in part by inhibition of the demethylase KDM4C (IC50=30 uM).

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Purity & Documentation Purity: 98.1% (HPLC) Select Batch:

Biological Activity

SD-70 is a small molecule tumor translocation inhibitor that inhibits the prostate cancer cell transcriptional program, in part by inhibition of the demethylase KDM4C (IC50=30 uM).
SD-70represses AR transcriptional program, increases H3K9me2 levels in 293T cells.
SD-70 inhibits tumor growth in CWR22Rv1 prostate cancer xenograft mice model.

Physicochemical Properties

M.Wt 310.353
Formula C18H18N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(furan-2-yl(8-hydroxyquinolin-7-yl)methyl)isobutyramide

References

1. Jin C, et al. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9235-40.

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