SDUY038 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : SDUY038

SDUY038 (SDUY-038)

Catalog No.: PC-27018Not For Human Use, Lab Use Only.

SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM.

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Biological Activity

SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM.
SDUY038 exhibits pan-antitumor activity (IC50=7-24 μM) by suppressing pERK expression.
SDUY038 significantly inhibited tumor growth in both xenograft and organoid models.

Physicochemical Properties

M.Wt	385.30
Formula	C17H18Cl2N2O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-amino-4-methylpiperidin-1-yl)(5-((2,3-dichlorophenyl)thio)furan-2-yl)methanone

References

1. Zhu C, et al. J Med Chem. 2024 Aug 8;67(15):13305-13323.

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SDUY038 (SDUY-038)

Biological Activity

Physicochemical Properties

References

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