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Chemical Structure : SF-3-030
Catalog No.: PC-72106Not For Human Use, Lab Use Only.
SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.
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SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM.
SF-3-030 showed selective inhibition of cancer cell lines with activating mutations in the ERK1/2 pathway.
SF-3-030 inhibited viability of four melanoma cell lines containing either BRAF or NRas mutations with IC50 of 5-10 uM.
SF-3-030 selectively regulates ERK-dependent immediate early gene expression, causes differential changes in AP-1 protein levels characterized by inhibition of Fra-1, FosB, and the alternative splice variant FosB2 but no effect on c-Fos levels, and induces ROS mediates inhibition of A375 cell proliferation.
| M.Wt | 324.365 | |
| Formula | C14H12O5S2 | |
| Appearance | Solid | |
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1. Ramon Martinez 3rd, et al. J Pharmacol Exp Ther. 2021 Jan;376(1):84-97.
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